Although the Resident Evil series has always had a narrative that draws inspiration from popular B-movie horror films, part of its success is also thanks to its unforgettable plots and characters, which have captured the audience’s attention with unexpected and well-executed twists.
Here are five of the most incredible and shocking plot twists in the Capcom series that created unforgettable moments.
Albert Wesker’s Betrayal – Resident Evil
Throughout the terrifying events in Spencer Mansion, S.T.A.R.S. Captain Albert Wesker is a mysterious figure. He rarely appears, but helps Chris Redfield and Jill Valentine by leaving supplies in safe areas. However, as the story unfolds, players realize that something is off about Wesker.
The truth comes to light in the secret laboratory of the Umbrella Corporation, where it’s revealed that Wesker was always working for Umbrella. He led the S.T.A.R.S. members to the mansion to collect data on the dangerous bio-organic weapons created by the corporation. After being killed by the Tyrant, he is revived thanks to a special virus he injected into himself, gaining superhuman abilities and preparing to carry out dangerous plans in the future.
Alfred Ashford Pretends to Be His Sister Alexia – Resident Evil Code Veronica
The Ashford twins, Alfred and Alexia, are the main antagonists in Resident Evil Code Veronica and start chasing Claire Redfield and Steve Burnside as they escape from Rockfort Island. However, after several encounters, Claire and Steve discover that there is no Alexia on the island.
It turns out to be a clever disguise by the insane Alfred, who is so obsessed with his sister’s disappearance that he impersonates her, even copying her voice. Unexpectedly, the real Alexia is alive and in a stasis pod at an Umbrella base in Antarctica.
Luis Serra Navarro Was a Researcher for Umbrella – Resident Evil 4 Remake
One of the best plot twists in Resident Evil 4 Remake involves the backstory of Luis Serra Navarro. In the original Resident Evil 4, Luis was simply described as a researcher working for the Los Illuminados who later regretted his actions. In the 2023 remake, his story is expanded, linking him directly to the Umbrella Corporation.
It’s revealed that Luis was once a researcher for Umbrella’s European branch, and his team was responsible for the experiments on the NE-Alpha parasite, which eventually led to the creation of the terrifying Nemesis in Resident Evil 3. Luis is now seeking redemption for his past mistakes and chooses to help Leon S. Kennedy as a way to atone for his sins.
Jill Valentine is Revealed as the Masked Assassin – Resident Evil 5
In Resident Evil 5, Jill is officially considered dead by the BSAA after sacrificing herself to save her long-time partner Chris from Wesker’s attack. Chris has always believed that Jill survived the fall, which is one of the main reasons he continues his mission in Africa related to the Uroboros virus. During the investigation with partner Sheva Alomar, they encounter a mysterious masked assassin working for Wesker.
When it’s time to confront Wesker, the masked figure is revealed to be Jill, under Wesker’s control. The emotional and intense battle that follows shows Chris freeing his longtime partner from Wesker’s influence. If a Resident Evil 5 Remake does happen, we can expect an even more emotional experience during this sequence.
Ethan Winters Died at the Baker House – Resident Evil Village
In Resident Evil Village, Ethan Winters appears to meet his end when Mother Miranda rips his heart out. However, his story doesn’t end there. Ethan is miraculously still alive—well, more or less. In a vision, Ethan meets Eveline, the bio-organic weapon he thought he had killed three years earlier in Baker House during the events of Resident Evil 7: Biohazard.
She reveals a shocking truth: Ethan had already died in that same house, killed by Jack Baker upon his arrival. Only the infection from the Megamicete allowed him to come back to life with supernatural regenerative abilities. This revelation sets him on a path to rescue his daughter, Rose, and prepare for a final showdown with Miranda.
And that’s all for some of the most incredible and shocking plot twists in the Resident Evil series. Which one shocked you the most? Let us know in the comments below!
